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In the last part of the chapter the author brings up the important subject of mutations. Activation through a precursor is defined as when an enzyme is activated by a precursor of its substrate and a nscesidad frequent case of this is activation of the enzyme by the substrate itself.

Bonus Vita: Jacques Monod: El Azar y la necesidad!

Monod spends some time stressing that there need be no chemical relationship between a substrate and an allosteric ligand and it is this “gratuity” that has allowed molecular evolution to make a huge network of interconnections and make each organism an autonomous functional unit. Once man extended his domain over the subhuman sphere and dominated his environment the main threat became other men and tribal warfare came to be an important evolutionary selection factor and this would favor group cohesion.

First the folding of the polypeptide sequence into globular proteins, then the association between proteins into organelles, thirdly the interactions between cells that make up tissue and organs, and lastly “coordination and differentiation of chemical activities via allosteric-type interactions” Monod, According to the in troduction the book’s title was inspired by a line attributed to Democritus, “Everything existing in the universe is the fruit of chance and necessity.

Next Monod reviews the primary and tertiary structure of proteins. He talks about the extraordinary specificity of action that enzymes display as exemplified by their ability to not only recognize a specific geometric isomer but an optical isomer as well. To them a being made sense and was understandable only through the purpose animating the being and so if mysterious objects, such as rocks, rivers, rain, and stars, exist it must also be for a purpose essentially there are no inanimate objects to them.

Toward the end of the preface Monod offers apology for any overly tedious or technical sections.

He lists the prime functions of the brain in mammals as control and aazr of neuromuscular activity, to set into action innate programs of action in response to stimuli, to integrate sensory inputs, to register, group, and associate significant events, and to represent and simulate.


That is why Mendel’s definition of the gene as the unvarying bearer of hereditary traits, its chemical identification by Avery confirmed by Hersheyand the elucidation by Watson and Crick of the structural basis of its replicative invariance, without any doubt constitute the most important discoveries ever made in biology.

El azar y la necesidad.

Jaime Echarri, Azar y necesidad en la filosofía de la vida de J. Monod. “In memoriam” – PhilPapers

He contends that these lines of thought abandon the postulate of objectivity and also contain the anthropocentric illusion. In advancing the concept of gene complexes that they called operons, Jacob and Monod postulated the existence of a class of genes that regulate the function of other genes by affecting the synthesis of messenger RNA. The author then spends some time developing the fact that the preceding sequence of amino acids had no bearing on what the next amino acid will be.

Monod mentions oligomeric globular proteins again and how they appear in aggregates containing geometrically equivalent protomer subunits associated into a non-covalent steric complex. Monod first brings up allosteric enzymes that are capable of recognizing compounds other than a substrate whose association with the enzyme protein has a modifying effect mood heightening or inhibiting the enzyme activity with respect to the substrate.

Here the author restates that nature is objective and does not pursue an end or have a purpose and he points out an apparent “epistemological [the study azr the origin, nature, methods, and limits of human knowledge] contradiction” between the teleonomic character of living organisms and the principle of objectivity.

Allosteric interactions are mediated by discrete shifts in the proteins structure and this allows certain proteins to assume different conformational states.

Synthesis of mRNA is blocked when the repressor is bound to the operator. The author points out that non-covalent interactions attain stability only through numerous interactions and when applied over short distances. The formation of a sterospecific complex between protein and substrate and the catalytic monid of a reaction within the complex he stresses again that the reaction is oriented and specified by the structure of the complex.

Monod starts off chapter I entitled “Of Strange Objects” with a consideration of the difference between natural and artificial objects and states that “the basic premise of the scientific method He goes on to state that he does not intend to make a thorough survey of modern biology but rather to “bring out the form of its key concepts and to point out their logical relationships with other areas of thought…it is an avowed attempt to extract the quintessence of the molecular azae of the code” Monod, xiii.


Through a series of aazar experiments and rhetorical questions he leads the reader on a difficult path to three characteristics of living beings.

At the end of this chapter Monod states that the thesis he “shall present in this book is that the biosphere does not contain a predictable class of objects or of events but necdsidad a particular wzar, compatible indeed with first principles, but not deducible from those principles and therefore essentially unpredictable” Monod, The “error” in the genetic message will be replicated with a high degree of fidelity.

The author defines the primary telonomic project “as consisting in the transmission from generation to generation of the invariance nefesidad characteristic of the species” Monod, 14 the preservation and multiplication of the species.

The similarity throughout all organisms of chemical machinery in both structure and function is set out. Monod reminds us that this reaction comes at the expense of chemical potential energy.

He then talks about the evolution of our ancestors including the development of upright posture which allowed them to become hunters. Monod again references his own work as he talks about the lactose system consisting of three proteins in Escherica coli.

Azar y necesidad en la filosofía de la vida de J. Monod. “In memoriam”

Monod points out that this animist line of thought is still present necesicad philosophy that makes no essential distinction between matter and life and frames biological evolution as a component of cosmic evolution evolutive force operating throughout the entire universe.

The author next turns his attention to the central nervous system. The sequence of the amino acid residues and the initial conditions determine the protein folding and therefore dictate the function. The author then says that due to the accelerating pace of cultural evolution, it no longer affects the genome and that selection does not favor the genetic survival of the fittest through a more numerous progeny.