British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.

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British anti-Lewisite Molecule of the Month – May

Thank You for Your Contribution! Dimercaprol has been used as an adjunct in the treatment of the acute encephalopathy of lead toxicity. The Royal Society of Chemistry.

Arsenic and some other heavy metals act by chemically reacting with adjacent thiol residues on metabolic brotish, creating a chelate complex that inhibits the affected enzyme’s activity. Dimercaprol has long been the mainstay of chelation therapy for lead or arsenic poisoning, [8] and it remains an essential drug.

British anti-Lewisite

Archived PDF from the original on 23 April Archived from the original on You may find it llewisite to search within the site to see how similar or related subjects are covered. Eagle and Magnuson found that 48 patients with severe or mild symptoms of arsenical encephalopathy were effectively treated with BAL Eagle and Magnuson Goals and duration of treatment. Dimercaprol Edetates Prussian blue. You can make it easier for us to review and, hopefully, publish your contribution by keeping a few points in mind.


It is a potentially toxic drug, and its use may bditish accompanied by multiple side effects. C Risk not ruled out.

BAL s use as the primary treatment for Wilson disease was short-lived because Walshe, inshowed the value of the less toxic chelating agent, penicillamine Walshe More About Dimercaprol 1 reference found in Britannica articles Assorted References arsenic poisoning In arsenic poisoning. Copper sulfate Ipecacuanha Syrup of ipecac.

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Improvements in synthesis resulted in the development of effective therapeutic ointments and solutions. Retrieved 22 April The content you are trying to view is available only to logged in, current MedLink Neurology subscribers.

Lewisite 2-chlorovinyldichoroarsine is an arsenic-based vesicant chemical warfare agent that was initially developed, although not used, by the United States during World War I. We welcome suggested improvements to any of our articles. There was a problem with your submission. Human and Experimental Toxicology Contact our editors with your feedback.

It was also considered effective in cases of intoxication with lewisihe, copper, and nickel Deichmann and Gerarde Please try again later. In This Article Introduction.

Rev Environ Contam Toxicol Internet URLs are the best. International journal of immunopathology and pharmacology. Parenteral British anti-Lewisite can be successfully used in lead poisoning if oral therapy fails.

Dimercaprolalso called British anti-lewisite BALdrug that was originally developed to combat the effects lewisitee the blister gas lewisitewhich was used in chemical warfare. Television TVthe electronic delivery of moving images and sound from a source to a receiver. Plans for the possible production ofpounds per year were developed Waters and Stock Discover some of the lewiisite interesting and trending topics of BAL is not generally recommended for use today because more efficient and safer chelators for oral or parenteral administration have been developed Andersen ; Blanusa et al ; Archer Dimercaprol was first made during World War II.

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British anti-Lewisite (dimercaprol): an amazing history.

Pharmacy and pharmacology portal Medicine portal. Chronicle of a Twentieth Century Medical Triumph. Retrieved from ” https: Nevertheless, BAL may still have some therapeutic value in patients who do not respond well to more modern agents Scheinberg and Sternlieb Help us improve this article!

Archived britsih the original on 21 December lwwisite Artificial intelligence AIthe ability of a digital computer or computer-controlled robot to perform…. Retrieved 8 December Dimercaprol has been found to form stable chelates in vivo with many other metals including inorganic mercuryantimonybismuthcadmiumchromiumcobaltgoldand nickel.

Our editors will review what you’ve submitted, and if it meets our criteria, we’ll add it to the article. The Editors of Encyclopaedia Britannica. This drug is not indicated in patients with iron, cadmium, selenium, silver, or uranium poisoning. Lorincz of the University ati Michigan has no relevant financial relationships to disclose. Other drawbacks include the need to administer it by painful intramuscular injection.

British anti-Lewisite was developed in as an antidote to lewisite, an arsenic-based chemical warfare agent.